The effects of 5-hydroxytryptophan on carrageenan-induced mouse paw oedemas

ABSTRACT Objective 5-Hydroxytryptophan is the precursor compound of serotonin biosynthesis. The oral absorption close to 100% and, unlike serotonin, it crosses blood-brain barrier freely. has been used as a food supplement for many years treat anxiety and depression. Recent studies have shown that suppresses pro-inflammatory mediators effective in some inflammatory diseases, such arthritis allergic asthma. However, role supplements on acute peripheral inflammation not investigated yet. In this study, vivo anti-inflammatory activity was evaluated with carrageenan-induced paw oedema test mice. Methods For investigation antiinflammatory activity, single doses (1.5, 5 20mg/kg) were given mice 1.5 hours prior carrageenan test. chronic same administered daily two weeks 14th day. To induce inflammation, 0.01mL 2% injected into paws Results Supplementation significantly reduced dose-independent manner which irrespective duration exposure (per cent inhibition experiments 35.4%, 20.9%, 24.0%, per 29.5%, 35.3%, 40.8% 1.5, 5, 20mg/kg, respectively). Conclusion Our findings demonstrate first time 5-HTP potential suppressing measures inflammation. It suggested that, apart from several diseases where believed play an important role, including depression, patients conditions may also benefit 5-HTP.